Research Publications
Asymmetric Catalysis  
“Catalytic Asymmetric Assembly of Stereodefined Propionate Units: An Enantioselective Total
Synthesis of (−)-Pironetin,” Nelson, S. G.; Shen, X.; Wasmuth, A. S.; Zhao, J.; Zhu, C. J. Am. Chem. Soc.
2006, 128, 7438-7439.  Read the C&E News Article.
“Au(I)-Catalyzed Pyrrole Additions to Enantioenriched Allenes in the Enantioselective Total Synthesis
of (–)-Rhazinilam,” Liu, Z.; Wasmuth, A. S.; Nelson, S. G. J. Am. Chem. Soc. 2006, 128, 10352-10353..
“Asymmetric Claisen Rearrangements Enabled by Catalytic Asymmetric Di(allyl) Ether Syntheses,”
Nelson, S. G.; Wang, K. J. Am. Chem. Soc. 2006, 128, 4232-4233.
“Catalytic Asymmetric Acyl Halide-Aldehyde Cyclocondensations,” Nelson, S. G.; Mills, P. M. Organic
Syntheses 2005, 82, 170-174.
“Cinchona Alkaloid-Lewis Acid Catalyst Systems for Effecting Highly Enantioselective Ketene-
Aldehyde Cycloadditions,” Zhu, C.; Shen, X.; Nelson, S. G.  J. Am. Chem. Soc. 2004, 126, 5352-5353.
“Catalytic Asymmetric Acyl Halide-Aldehyde Cyclocondensation Reactions of Substituted Ketenes,”
Nelson, S. G.; Zhu, C.; Shen, X.  J. Am. Chem. Soc. 2004, 126, 14-15.
“Lewis Acidity Expressed in Neutral Electron-Rich Aluminum(III) Complexes: An Example of Ligand-
Defined Catalysis,” Nelson, S. G.; Kim, B.-K.; Peelen, T. J.  J. Am. Chem. Soc.  2000; 122; 9318-9319.
“Catalytic Asymmetric Propionate Aldol Reactions via Acyl Halide-Aldehyde Cyclocondensations,”
Nelson, S. G.; Wan, Z.  Org. Lett. 2000, 2, 1883-1886.
“Asymmetric beta-Amino Acid Synthesis Based on Catalytic Asymmetric Acyl Halide-Aldehyde
Cyclocondensations,” Nelson, S. G.; Spencer, K. L. Angew. Chem. Int. Ed. 2000, 39, 1323-1325.
“Catalytic Asymmetric Acyl Halide-Aldehyde Cyclocondensations. A Strategy for Catalyzed Cross
Aldol Reactions,” Nelson, S. G.; Peelen, T. J.; Wan. Z.  J. Am. Chem. Soc. 1999, 121, 9742-9743.
“Catalyzed Acyl Halide-Aldehyde Cyclocondensations. New Insights into the Design of Catalytic
Cross Aldol Reactions,” Nelson, S. G.; Wan. Z.; Peelen, T. J.; Spencer, K. L.  Tetrahedron Lett. 1999, 40,
6535-6540.
“Mechanistic Alternatives in Lewis Acid-Catalyzed Acyl Halide-Aldehyde Cyclocondensations,”
Nelson, S. G.; Peelen, T. J.; Wan, Z.  Tetrahedron Lett. 1999, 40, 6541-6543.
“Asymmetric Synthesis of Monodentate Phosphine Ligands Based on Chiral eta6-Cr[arene]
Templates,” Nelson, S. G.; Hilfiker, M. A. Org. Lett. 1999, 1, 1379-1382
"Catalyzed Enantioselective Aldol Additions of Latent Enolate Equivalents,"  Nelson, S. G.  
Tetrahedron: Asymm. 1998, 9, 357-389.
"Ligand-Modified Catalysts for the McMurry Pinacol Reaction," Nelson, S. G.; Lipski, T. A.; Hilfiker, M.
A. J. Org. Chem. 1997, 62, 4566-4567.
New Reaction Discovery
“Strategies for Expanding Structural Diversity Available from Olefin Isomerization-Claisen
Rearrangement Reactions,” Stevens, B. D.; Bungard, C. J.; Nelson, S. G. J. Org. Chem. ASAP Articles.
“Tandem Sakurai-Aldol Addition Reactions as a Route to Structurally Complex Carbocycles,” Stevens,
B. D.; Nelson, S. G. J. Org. Chem. 2005, 70, 4375-4379.
“Catalyzed Olefin Isomerization Leading to Highly Stereoselective Claisen Rearrangements of
Aliphatic Allyl Vinyl Ethers,” Nelson, S. G.; Bungard, C. J.; Wang, K.  J. Am. Chem. Soc. 2003, 125,
13000-13001.
“Divergent Reaction Pathways in Amine Additions to ß-Lactone Electrophiles.  An Application to ß-
Peptide Synthesis,” Nelson,S. G.; Spencer, K. L.; Cheung, W. S.; Mamie, S. J.  Tetrahedron 2002, 58,
7081-7091.
“SN2 Ring Opening of beta-Lactones: An Alternative to Catalytic Asymmetric Conjugate Additions,”  
Nelson, S. G.; Wan, Z.; Stan, M. A.  J. Org. Chem.  2002, 67, 4680-4683.
“Enantioenriched Dihydropyrones from ß-Lactone Templates,” Zipp, G. G.; Hilfiker, M. A.; Nelson, S. G.  
Org. Lett. 2002, 4, 1823-1826.
“Optically Active Allenes form beta-Lactone Templates: Total Synthesis of (–)-Malyngolide,” Wan, Z.;
Nelson, S. G.  J. Am. Chem. Soc. 2000, 122, 10470-10471.
“Sequential Catalyzed Acyl Halide Aldehyde Cyclocondensations and Enzymatic Resolution as a
Route to Enantiomerically Enriched beta-Lactones,” Nelson, S. G.; Spencer, K. L.  J. Org. Chem. 2000,
65, 1227-1230.
Complex Molecule Synthesis
“Au(I)-Catalyzed Pyrrole Additions to Enantioenriched Allenes in the Enantioselective Total Synthesis
of (–)-Rhazinilam,” Liu, Z.; Wasmuth, A. S.; Nelson, S. G. J. Am. Chem. Soc. accepted for publication.
“Catalytic Asymmetric Assembly of Stereodefined Propionate Units: An Enantioselective Total
Synthesis of (−)-Pironetin,” Nelson, S. G.; Shen, X.; Wasmuth, A. S.; Zhao, J.; Zhu, C. J. Am. Chem. Soc.
2006, 128, 7438-7439.
“Asymmetric Claisen Rearrangements Enabled by Catalytic Asymmetric Di(allyl) Ether Syntheses,”
Nelson, S. G.; Wang, K. J. Am. Chem. Soc. 2006, 128, 4232-4233.
“Amphidinolide B: Asymmetric Synthesis of a C7-C20 Synthon,” Gopalarathnam, A.; Nelson, S. G. Org.
Lett. 2006, 8, 7-10.
“A De Novo Enantioselective Synthesis of (–)-Laulimalide,” Nelson, S. G.; Cheung, W. S.; Kassick, A. J.;
Hilfiker, M. A.  J. Am. Chem. Soc. 2002, 124, 13654-13565.
“Optically Active Allenes form ß-Lactone Templates: Total Synthesis of (–)-Malyngolide,” Wan, Z.;
Nelson, S. G.  J. Am. Chem. Soc. 2000, 122, 10470-10471.
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